Frontline Plus Flea & Tick Treatment Large Dogs 45-88 lbs
The #1 trusted name in flea & tick protection Fleas and ticks don't just bother your dog — they spread disease, trigger allergic reactions, and multiply fast if left untreated. Frontline Plus for Dogs stops them at every stage of...
- Kills Fleas, Eggs & Larvae, breaking the full life cycle
- Kills Ticks including Lyme-disease-capable ticks
- Kills Chewing Lice
- Waterproof After 24 Hours
- Continuous Monthly Protection via sebaceous gland redistribution
- Trusted 20+ Years, #1 name in flea/tick prevention
- Easy Single-Point Application
The #1 trusted name in flea & tick protection
Fleas and ticks don't just bother your dog — they spread disease, trigger allergic reactions, and multiply fast if left untreated. Frontline Plus for Dogs stops them at every stage of the life cycle, delivering fast-acting, waterproof protection that lasts a full 30 days from a single application.
For large breed dogs 45–88 lbs, 8 weeks and older. Includes 3 monthly doses.
Full ingredient and material breakdown, sourcing region, and third-party testing notes are printed on the packaging and listed here at launch.
Measure at the widest point and size up if you land between two sizes. Free exchanges within 30 days if the fit is wrong.
Free shipping on orders over $49, otherwise a flat $5.95. Most orders arrive in 2–5 business days. Unused items can be returned for 30 days.
Product details
⭐ Key features
- 🦟 Kills fleas, eggs & larvae — Breaks the entire flea life cycle, not just adult fleas, preventing new infestations before they start.
- 🕷️ Kills ticks — Including ticks capable of transmitting Lyme disease, protecting your dog during walks, hikes and yard time.
- 🐛 Kills chewing lice — Broad-spectrum protection beyond just fleas and ticks.
- 💧 Waterproof after 24 hours — Stays effective through baths, swimming and rain without losing protection.
- 🔄 Continuous monthly protection — Deposits into the sebaceous glands and continuously redistributes across the coat for a full 30 days.
- 🐕 Trusted 20+ years — America's #1 name in flea and tick prevention, backed by decades of veterinary trust.
- 🧴 Easy single-point application — One quick application between the shoulder blades covers your dog's entire body.
🐾 Suitable for
Large breed dogs 45–88 lbs, 8 weeks and older. Includes 3 monthly doses (90-day supply).
📋 How to use
Part your dog's coat between the shoulder blades and apply the entire applicator directly onto the skin. Repeat every 30 days. Avoid contact with the treated area until dry.
⚠️ Safety information
- For external use only.
- Do not use on puppies under 8 weeks or under 5 lbs.
- Do not use on cats.
- Read the full label before each use, and consult your veterinarian with any concerns.
📦 Product details
| Dog Weight | 45–88 lbs (large) |
| Doses | 3 applications (3 months) |
| Active Ingredients | Fipronil 9.8%, (S)-methoprene 8.8% |
| Form | Liquid topical |
| Age | 8 weeks & older |
| Waterproof | After 24 hours |
Frequently asked questions
Large breed dogs weighing 45 to 88 lbs, from 8 weeks old. Always use the dose made for your dog's weight range.
No. This is a dog-only formulation. Cats need the Frontline Plus product made for cats.
Once a month, on roughly the same date each time. One application lasts a full 30 days.
Yes, after 24 hours. Once absorbed it stays effective through baths, swimming and rain.
Part the coat between the shoulder blades and apply to the skin in a single spot, where your dog cannot lick it off.
Many treatments only kill adult fleas. This one breaks the whole life cycle, killing eggs and larvae too, so an infestation cannot rebuild itself.